8-CPT-2Me-cAMP sodium
Cat. No.：YN322585
| 产品名称: | 8-CPT-2Me-cAMP sodium |
| CAS No.: | 634207-53-7 |
| Chemical Name: | 8-[(4-chlorophenyl)thio]-2'-O-methyl-adenosine cyclic 3',5'-(hydrogen phosphate), monosodium salt |
| Synonyms: | |
| 分子量: | 507.8 |
| 分子式: | C17H16N5O6ClPS • Na |
| SMILES: | O=P1([O-])O[C@H]2[C@@H](OC)[C@H](N3C(SC4=CC=C(Cl)C=C4)=NC5=C3N=CN=C5N)O[C@@H]2CO1.[Na+] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 8-CPT-2Me-cAMP sodium 是exchange proteins activated by cAMP (Epac)的选择性激动剂，Epac 是小 GTP 酶 Rap1 和 Rap2 的 cAMP 敏感性鸟嘌呤核苷酸交换因子 (GEF)。8-CPT-2Me-cAMP sodium 激活 Epac1(EC50=2.2 μM)，但不激活 PKA(EC50>10 μM)。8-CPT-2Me-cAMP 在体外刺激 Epac 介导的 Ca2+在胰腺 β 细胞中的释放。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Breckler, M., Berthouze, M., Laurent, A.C., et al.Rap-linked cAMP signaling Epac proteins: Compartmentation, functioning and disease implicationsCell. Signal.23(8),1257-1266(2011)
Rehmann, H., Schwede, F., Doskeland, S.O., et al.Ligand-mediated activation of the cAMP-responsive guanine nucleotide exchange factor EpacJ. Biol. Chem.278(40),38548-38556(2003)
Christensen, A.E., Selheim, F., de Rooij, J., et al.cAMP analog mapping of Epac1 and cAMP kinase. Discriminating analogs demonstrate that Epac and cAMP kinase act synergistically to promote PC-12 cell neurite extensionJ. Biol. Chem.278(37),35394-35402(2003)
Kang, G., Chepurny, O.G., Malester, B., et al.cAMP sensor Epac as a determinant of ATP-sensitive potassium channel activity in human pancreatic β cells and rat INS-1 cellsJ. Physiol.573(Pt 3),595-609(2006)
Eid, A.H., Chotani, M.A., Mitra, S., et al.Cyclic AMP acts through Rap1 and JNK signaling to increase expression of cutaneous smooth muscle α2C-adrenoceptorsAm. J. Physiol. Heart Circ. Physiol.295(1),H266-H272(2008)
Quan, Y., Jiang, J., and Dingledine, R.EP2 receptor signaling pathways regulate classical activation of microgliaJ. Biol. Chem.288(13),9293-9302(2013)
