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CAY10580

Cat. No.:YN322590

  • CAS No. :64054-40-6

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    • 参考文献
    • 产品名称: CAY10580
      CAS No.: 64054-40-6
      Chemical Name: 2-(3-hydroxyoctyl)-5-oxo-1-pyrrolidineheptanoic acid
      Synonyms:
      分子量:341.5
      分子式:C19H35NO4
      SMILES:CCCCCC(O)CCC1CCC(=O)N1CCCCCCC(=O)O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
      Select Batch:
      Purity: 98%
    • 产品描述: CAY10580是有效和选择性的前列腺素EP4受体 (EP4) 激动剂 (Ki=35 nM)。
      IC50和靶点: [{name:"EP4:35 nM (Ki)"},{name: "EP2:3000 nM (Ki)"},{name: "EP3:2000 nM (Ki)"},{name: "EP1:>3000 nM (Ki)"}]
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Li, M., Thompson, D.D., and Paralkar, V.M.Prostaglandin E2 receptors in bone formationInt. Orthop.31(6),767-772(2007)

      Hawcroft, G., Ko, C.W.S., and Hull, M.A.Prostaglandin E2-EP4 receptor signalling promotes tumorigenic behaviour of HT-29 human colorectal cancer cellsOncogene26(21),3006-3019(2007)

      Babaev, V.R., Chew, J.D., Ding, L., et al.Macrophage EP4 deficiency increases apoptosis and suppresses early atherosclerosisCell Metab.8(6),492-501(2008)

      Billot, X., Chateauneuf, A., Chauret, N., et al.Discovery of a potent and selective agonist of the prostaglandin EP4 receptorBioorg. Med. Chem. Lett.13(6),1129-1132(2003)

      Smith, R.L., Lee, T., Gould, N.P., et al.Prostaglandin isosteres. 1. (8-Aza-, 8,10-Diaza-, and 8-Aza-11-thia)-9-oxoprostanoic acids and their derivativesJ. Med. Chem.20(10),1292-1299(1977)

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