(R)-SLV 319
Cat. No.：YN322594
| 产品名称: | (R)-SLV 319 |
| CAS No.: | 656827-86-0 |
| Chemical Name: | 3-(4-chlorophenyl)-N-[(4-chlorophenyl)sulfonyl]-4,5-dihydro-N'-methyl-4R-phenyl-1H-pyrazole-1-carboximidamide |
| Synonyms: | |
| 分子量: | 487.4 |
| 分子式: | C23H20Cl2N4O2S |
| SMILES: | C/N=C(\NS(=O)(=O)c1ccc(Cl)cc1)/N1N=C(c2ccc(Cl)cc2)[C@@H](C1)c1ccccc1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | (R)-SLV 319 是一种有效且具有选择性的大麻素受体 1 (CB1)拮抗剂，Ki为 894 nM。(R)-SLV 319 是 SLV 319 的右旋对映体。 |
| IC50和靶点: | [{name:"CB1:894 nM (Ki)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Lange, J.H.M., Coolen, H.K.A.C., van Stuivenberg, H.H., et al.Synthesis, biological properties, and molecular modeling investigations of novel 3,4-diarylpyrazolines as potent and selective CB1 cannabinoid receptor antagonistsJ. Med. Chem.47(3),627-643(2004)
Lange, J.H.M., van Stuivenberg, H.H., Veerman, W., et al.Novel 3,4-diarylpyrazolines as potent cannabinoid CB1 receptor antagonists with lower lipophilicityBioorg. Med. Chem. Lett.15,4794-4798(2005)
