SKF 83959 hydrobromide
Cat. No.：YN322600
| 产品名称: | SKF 83959 hydrobromide |
| CAS No.: | 67287-95-0 |
| Chemical Name: | 6-chloro-2,3,4,5-tetrahydro-3-methyl-1-(3-methylphenyl)-1H-3-benzazepine-7,8-diol, monohydrobromide |
| Synonyms: | SKF-83959 HBr; SKF-83959; SKF83959; SKF 83959. |
| 分子量: | 398.72158 |
| 分子式: | C18H20ClNO2 • HBr |
| SMILES: | OC(C(O)=C1)=C(Cl)C2=C1C(CN(C)CC2)C3=CC=CC(C)=C3.Br |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SKF83959 hydrobromide 是一种有效的选择性多巴胺D1-like受体部分激动剂。 SKF83959 hydrobromideKi对大鼠D1，D5，D2和 D3的值分别为 1.18, 7.56, 920 和 399 nM。SKF83959 hydrobromide 是一种有效的sigma (σ)-1受体变构调节剂。SKF83959 hydrobromide 属于 benzazepine 家族，对认知功能障碍有改善作用。SKF83959 hydrobromide 可用于研究阿尔茨海默病和抑 |
| IC50和靶点: | [{name:"D1 Receptor:1.18 nM (Ki)"},{name: "D5 Receptor:7.56 nM (Ki)"},{name: "D2 Receptor:920 nM (Ki)"},{name: "D3 Receptor:399 nM (Ki)'}, 'sigma (σ)-1'] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Neumeyer, J.L., Kula, N.S., Bergman, J., et al.Receptor affinities of dopamine D1 receptor-selective novel phenylbenzazepinesEur. J. Pharmacol.474(2-3),137-140(2003)
Lee, S.-M., Kant, A., Blake, D., et al.SKF-83959 is not a highly-biased functionally selective D1 dopamine receptor ligand with activity at phospholipase CNeuropharmacology86,145-154(2014)
Li, G.-Y., Li, T., Fan, B., et al.The D1 dopamine receptor agonist, SKF83959, attenuates hydrogen peroxide-induced injury in RGC-5 cells involving the extracellular signal-regulated kinase/p38 pathwaysMol. Vis.18,2882-2895(2012)
Perreault, M.L., Fan, T., Banasikowski, T.J., et al.The atypical dopamine receptor agonist SKF 83959 enhances hippocampal and prefrontal cortical neuronal network activity in a rat model of cognitive dysfunctionEur. J. Neurosci.,(2017)
Guo, L., Zhao, J., Jin, G., et al.SKF83959 is a potent allosteric modulator of sigma-1 receptorMol. Pharmacol.83(3),577-586(2013)
