Pirmenol
Cat. No.：YN322603
| 产品名称: | Pirmenol |
| CAS No.: | 68252-19-7 |
| Chemical Name: | rel-α-[3-[(2R,6S)-2,6-dimethyl-1-piperidinyl]propyl]-α-phenyl-2-pyridinemethanol |
| Synonyms: | Cl-845 free base; (± |
| 分子量: | 338.48648 |
| 分子式: | C22H30N2O |
| SMILES: | OC(C1=NC=CC=C1)(C2=CC=CC=C2)CCCN3[C@H](C)CCC[C@@H]3C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Pirmenol 是一种具有口服活性的抗心律失常剂。Pirmenol 通过阻断毒蕈碱性受体 (mAchR) 来抑制IK.ACh(IC50: 0.1 μM)。可用于心血管疾病的研究，如心房颤动。Pirmenol 通过阻断毒蕈碱性受体 (mAchR) 来抑制IK.ACh(IC50: 0.1 μM)。Pirmenol 可用于心血管疾病的研究，如心房颤动。 |
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Sawanobori, T., Adaniya, H., Yamashita, S., et al.Electrophysiologic and antiarrhythmic actions of pirmenol on rabbit and guinea pig cardiac preparationsJ. Cardiovasc. Pharmacol.16(6),975-983(1990)
Kaplan, H.R., Mertz, T.E., and Steffe, T.J.Preclinical pharmacology of pirmenolAm. J. Cardiol.59(16),2H-9H(1987)
Steffe, T.J., Mertz, T.E., Hastings, S.G., et al.CL-845 (pirmenol hydrochloride): A new orally effective long-acting antiarrhythmic agentJ. Pharmacol. Exp. Ther.214(1),50-57(1980)
