JNJ-5207787
Cat. No.：YN322604
| 产品名称: | JNJ-5207787 |
| CAS No.: | 683746-68-1 |
| Chemical Name: | (2E)-N-(1-acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyanophenyl)-N-[1-(2-cyclopentylethyl)-4-piperidinyl]-2-propenamide |
| Synonyms: | |
| 分子量: | 510.7 |
| 分子式: | C32H38N4O2 |
| SMILES: | O=C(/C=C/C1=CC=CC(C#N)=C1)N(C2=CC=C(CCN3C(C)=O)C3=C2)C4CCN(CCC5CCCC5)CC4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | JNJ-5207787 是一种非肽类，选择性且可穿透血脑屏障的神经肽 Y Y2受体 (Y2)拮抗剂。JNJ-5207787 抑制 YY 肽 (PYY) 和人 Y2受体，大鼠 Y2受体结合，pIC50分别为 7.0 和 7.1。JNJ-5207787 相对于人 Y1，Y4和 Y5受体具有 >100 倍的选择性。 |
| IC50和靶点: | [{name:"human Y2 receptor:7.0 (pIC50)"},{name: "rat Y2 receptor:7.1 (pIC50)"}] |
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| Clinical Trial: | |
| Solvent & Solubility: |
Bonaventure, P., Nepomuceno, D., Mazur, C., et al.Characterization of N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyano-phenyl)-N-[1-(2-cyclopentyl-ethyl)-piperidin-4yl]acrylamide (JNJ-5207787), a small molecule antagonist of the neuropeptide Y Y2 receptorJ. Pharm. Exp. Ther.308(3),1130-1137(2004)
Mittapalli, G.K., and Roberts, E.Ligands of the neuropeptide Y Y2 receptorBioorg. Med. Chem. Lett.24(2),430-441(2014)
