BMS-986187
Cat. No.：YN322605
CAS No. ：684238-37-7
| 产品名称: | BMS-986187 |
| CAS No.: | 684238-37-7 |
| Chemical Name: | 3,4,5,6,7,9-hexahydro-3,3,6,6-tetramethyl-9-[4-[(2-methylphenyl)methoxy]phenyl]-1H-xanthene-1,8(2H)-dione |
| Synonyms: | BMS986187 |
| 分子量: | 470.6 |
| 分子式: | C31H34O4 |
| SMILES: | CC1=C(COC2=CC=C(C3C(C(CC(C)(C)C4)=O)=C4OC(CC(C)(C)C5)=C3C5=O)C=C2)C=CC=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BMS-986187 是一种δ 阿片受体选择性正变构调节剂 (PAM)，EC50为 0.03 μM，pKB为 6.02 (~1 μM)。BMS-986187 在 μ 受体上没有可观察到的 PAM 活性 (EC50=3 μM)。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Burford, N.T., Livingston, K.E., Canals, M., et al.Discovery, synthesis, and molecular pharmacology of selective positive allosteric modulators of the δ-opioid receptorJ. Med. Chem.58(10),4220-4229(2015)
