Otenabant Hydrochloride
Cat. No.：YN322606
| 产品名称: | Otenabant Hydrochloride |
| CAS No.: | 686347-12-6 |
| Chemical Name: | 1-[8-(2-chlorophenyl)-9-4-chlorophenyl)-9H-purine-6-yl]-4-ethylamino)-4-piperidinecarboxamide, monohydrochloride |
| Synonyms: | CP 945598 Hydrochloride |
| 分子量: | 546.9 |
| 分子式: | C25H25Cl2N7O • HCl |
| SMILES: | ClC(C=CC=C1)=C1C2=NC3=C(N4CCC(NCC)(C(N)=O)CC4)N=CN=C3N2C5=CC=C(Cl)C=C5.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Otenabant (CP945598)盐酸盐是CB1受体高亲和性拮抗剂，Ki为0.7 nM。 |
| IC50和靶点: | |
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Griffith, D.A., Hadcock, J.R., Black, S.C., et al.Discovery of 1-[9-(4-chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl]-4-ethylaminopiperidine-4-carboxylic acid amide hydrochloride (CP-945,598), a novel, potent, and selective cannabinoid type 1 receptor antagonistJ. Med. Chem.52(2),234-237(2009)
Hadcock, J.R., Griffith, D.A., Iredale, P.A., et al.In vitro and in vivo pharmacology of CP-945,598, a potent and selective cannabinoid CB1 receptor antagonist for the management of obesityBiochem. Biophys. Res. Commun.394(2),366-371(2010)
