ML-193
Cat. No.：YN322617
CAS No. ：713121-80-3
| 产品名称: | ML-193 |
| CAS No.: | 713121-80-3 |
| Chemical Name: | N-[4-[[(3,4-dimethyl-5-isoxazolyl)amino]sulfonyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)-4-quinolinecarboxamide |
| Synonyms: | CID 1261822 |
| 分子量: | 527.6 |
| 分子式: | C28H25N5O4S |
| SMILES: | O=C(C1=C(C=C(C)C=C2C)C2=NC(C3=CC=CC=N3)=C1)NC4=CC=C(S(NC5=C(C)C(C)=NO5)(=O)=O)C=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ML-193 (CID 1261822) 是一种有效和选择性的GPR55拮抗剂，IC50值为 221 nM。ML-193 对GPR55的选择性是GPR35，CB1 和CB2的 27 倍以上。ML-193 可以改善帕金森氏病 (PD) 大鼠的运动和感觉运动缺陷。 |
| IC50和靶点: | |
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Heynen-Genel, S., Dahl, R., Shi, S., et al.Screening for selective ligands for GPR55NIH Molecular Libraries,(2010)
Kotsikorou, E., Sharir, H., Shore, D.M., et al.Identification of the GPR55 antagonist binding site using a novel set of high-potency GPR55 selective ligandsBiochemistry52(52),9456-9469(2013)
Deliu, E., Sperow, M., Console-Bram, L., et al.The lysophosphatidylinositol receptor GPR55 modulates pain perception in the periaqueductal grayMol. Pharmacol.88(2),265-272(2015)
