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Metoclopramide hydrochloride

Cat. No.:YN322621

  • CAS No. :7232-21-5

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    • 产品名称: Metoclopramide hydrochloride
      CAS No.: 7232-21-5
      Chemical Name: 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxy-benzamide, monohydrochloride
      Synonyms:盐酸甲氧氯普胺
      分子量:336.3
      分子式:C14H22ClN3O2 • HCl
      SMILES:ClC1=CC(C(NCCN(CC)CC)=O)=C(OC)C=C1N.Cl
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Metoclopramide hydrochloride 是一种有效和具有口服活性的5-HT3和多巴胺D2受体拮抗剂,IC50值分别为 308 nM 和 483 nM。Metoclopramide hydrochloride 可用于恶心呕吐、胃食管反流和胃轻瘫的研究。
      IC50和靶点: [{name:"5-HT3 Receptor:308 nM (IC50)"},{name: "D2 Receptor:483 nM (IC50)"}]
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    • Youssefyeh, R.D., Campbell, H.F., Klein, S., et al.Development of high-affinity 5-HT3 receptor antagonists. 1. Initial structure-activity relationship of novel benzamidesJ. Med. Chem.35(5),895-903(1992)

      Hirokawa, Y., Harada, H., Yoshikawa, T., et al.Synthesis and structure-activity relationships of 4-amino-5-chloro-N-(1,4-dialkylhexahydro-1,4-diazepin-6-yl)-2-methoxybenzamide derivatives, novel and potent serotonin 5-HT3 and dopamine D2 receptors dual antagonistChem. Pharm. Bull. (Tokyo)50(7),941-959(2002)

      Chemnitius, J.M., Haselmeyer, K.H., Gonska, B.D., et al.Indirect parasympathomimetic activity of metoclopramide: Reversible inhibition of cholinesterases from human central nervous system and bloodPharmacol. Res.34(1-2),65-72(1996)

      Harrington, R.A., Hamilton, C.W., Brogden, R.N., et al.Metoclopramide. An updated review of its pharmacological properties and clinical useDrugs25(5),451-494(1983)

      Altar, C.A., Boyar, W.C., Wasley, A., et al.Dopamine neurochemical profile of atypical antipsychotics resembles that of D-1 antagonistsNaunyn Schmiedebergs Arch. Pharmacol.338(2),162-168(1988)

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