Acifran
Cat. No.：YN322623
| 产品名称: | Acifran |
| CAS No.: | 72420-38-3 |
| Chemical Name: | 4,5-dihydro-5-methyl-4-oxo-5-phenyl-2-furancarboxylic acid |
| Synonyms: | AY 25712 |
| 分子量: | 218.2054 |
| 分子式: | C12H10O4 |
| SMILES: | O=C1C(C2=CC=CC=C2)(C)OC(C(O)=O)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Acifran (AY 25712) 是一种抗高血脂活性分子，是具有口服活性的GPR109A(HM74A) 和 GPR109B（Niacin 的高亲和力和低亲和力受体）的激动剂。 |
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Wise, A., Foord, S.M., Fraser, N.J., et al.Molecular identification of high and low affinity receptors for nicotinic acidJ. Biol. Chem.278(11),9869-9874(2003)
Mahboubi, K., Witman-Jones, T., Adamus, J.E., et al.Triglyceride modulation by acifran analogs: Activity towards the niacin high and low affinity G protein-coupled receptors HM74A and HM74Biochem. Biophys. Res. Commun.340(2),482-490(2006)
Cayen, M.N., Kallai-Sanfacon, M.A., Dubuc, J., et al.Evaluation of the lipid-lowering activity of AY-25,712 in ratsAtherosclerosis45(3),267-279(1982)
