Dopamine D3 receptor ligand-3
Cat. No.：YN322632
| 产品名称: | Dopamine D3 receptor ligand-3 |
| CAS No.: | 75272-39-8 |
| Chemical Name: | rel-5-chloro-2-methoxy-4-(methylamino)-N-[(2R,3R)-2-methyl-1-(phenylmethyl)-3-pyrrolidinyl]-benzamide |
| Synonyms: | YM-09151-2; Emilace; Emonapride |
| 分子量: | 387.9 |
| 分子式: | C21H26ClN3O2 |
| SMILES: | CNC1=C(Cl)C=C(C(N[C@H]2[C@@H](C)N(CC3=CC=CC=C3)CC2)=O)C(OC)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Nemonapride 是一种高效的多巴胺 D2受体拮抗剂，其Ki为 0.06 nM。Nemonapride 也能激活5-HT1A受体，其IC50为34 nM。Nemonapride 是一种抗精神病活性分子，易透过血脑屏障，在动物中表现出强大的抗精神病作用。 |
| IC50和靶点: | [{name:"5-HT1A Receptor:34 nM (IC50)"},{name: "D2 Receptor:0.06 nM (Ki)"}] |
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Terai, M., Usuda, S., Kuroiwa, I., et al.Selective binding of YM-09151-2, a new potent neuroleptic, to D2-dopaminergic receptorsJpn. J. Pharmacol.33(4),749-755(1983)
Seeman, P., and Van Tol, H.H.M.Dopamine receptor pharmacologyTrends Pharmacol. Sci.15(7),264-270(1994)
Ujike, H., Akiyama, K., and Kuroda, S.[3H]YM-09151-2 (nemonapride), a potent radioligand for both sigma 1 and sigma 2 receptor subtypesNeuroreport7(5),1057-1061(1996)
Assié, M.-B., Cosi, C., and Koek, W.5-HT1A receptor agonist properties of the antipsychotic, nemonapride: comparison with bromerguride and clozapineEur. J. Pharmacol.334(2-3),141-147(1997)
