(R)-(-)-α-Methylhistamine dihydrochloride
Cat. No.：YN322633
| 产品名称: | (R)-(-)-α-Methylhistamine dihydrochloride |
| CAS No.: | 75614-89-0 |
| Chemical Name: | (αR)-methyl-1H-imidazole-5-ethanamine, dihydrochloride |
| Synonyms: | |
| 分子量: | 198.1 |
| 分子式: | C6H11N3 • 2HCl |
| SMILES: | C[C@@H](N)CC1=CN=CN1.Cl.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | (R)-(-)-α-Methylhistamine dihydrochloride 是一种有效，选择性和可透过血脑屏障的H3组胺受体激动剂，Kd值为 50.3 nM。(R)-(-)-α-Methylhistamine dihydrochloride 可增强记忆力，减轻大鼠的记忆力障碍。 |
| IC50和靶点: | [{name:"H3 receptor:50.3 nM (Kd)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Ohkubo, T., Shibata, M., Inoue, M., et al.Autoregulation of histamine release via the histamine H3 receptor on mast cells in the rat skinArch. Int. Pharmacodyn. Ther.328(3),307-314(1994)
Barocelli, E., Ballabeni, V., Chiavarini, M., et al.R-α-methylhistamine-induced inhibition of gastric acid secretion in pylorus-ligated rats via central histamine H3 receptorsBr. J. Pharmacol.115(7),1326-1330(1995)
Yokoyama, F., Yamauchi, M., Oyama, M., et al.Anxiolytic-like profiles of histamine H3 receptor agonists in animal models of anxiety: A comparative study with antidepressants and benzodiazepine anxiolyticPsychopharmacol. (Berl)205(2),177-187(2009)
Poveda, R., Fernández-Dueñas, V., Fernández, A., et al.Synergistic interaction between fentanyl and the histamine H3 receptor agonist R-(α)-methylhistamine, on the inhibition of nociception and plasma extravasation in miceEur. J. Pharmacol.,53-56(2006)
