Mepenzolate bromide
Cat. No.：YN322637
| 产品名称: | Mepenzolate bromide |
| CAS No.: | 76-90-4 |
| Chemical Name: | 3-[(2-hydroxy-2,2-diphenylacetyl)oxy]-1,1-dimethyl-piperidinium, monobromide |
| Synonyms: | 溴美喷酯 |
| 分子量: | 420.3 |
| 分子式: | C21H26NO3 • Br |
| SMILES: | C[N+]1(C)CCCC(OC(C(O)(C2=CC=CC=C2)C3=CC=CC=C3)=O)C1.[Br-] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Mepenzolate bromide 是一种有效的，具有口服活性的毒蕈碱受体拮抗剂，对hM2R和hM3R的Ki分别为 0.68 和 2.6 nM。Mepenzolate bromide 可用于抑制与肠易激综合征相关的胃肠道过度运动。Mepenzolate bromide 是一种GPR109A抑制剂. |
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Yamashita, Y., Tanaka, K.-I., Asano, T., et al.Synthesis and biological comparison of enantiomers of mepenzolate bromide, a muscarinic receptor antagonist with bronchodilatory and anti-inflammatory activitiesBioorg. Med. Chem.22(13),3488-3497(2014)
Buckley, J.P., DeFeo, J.J., and Reif, E.C.The comparative antispasmodic activity of N-methyl-3-piperidyl diphenylglycolate methobromide (JB-340) and atropine sulfateJ. Am. Pharm. Assoc.46(10),592-594(1957)
Tanaka, K.-I., Ishihara, T., Sugizaki, T., et al.Mepenzolate bromide displays beneficial effects in a mouse model of chronic obstructive pulmonary diseaseNat. Commun.4:2686,(2013)
Zheng, Y., Wang, X., Ji, S., et al.Mepenzolate bromide promotes diabetic wound healing by modulating inflammation and oxidative stressAm. J. Transl. Res.8(6),2738-2747(2016)
