β-Secretase Inhibitor IV
Cat. No.：YN380410
| 产品名称: | β-Secretase Inhibitor IV |
| CAS No.: | 797035-11-1 |
| Chemical Name: | N1-[(1S,2R)-3-(cyclopropylamino)-2-hydroxy-1-(phenylmethyl)propyl]-5-[methyl(methylsulfonyl)amino]-N3-[(1R)-1-phenylethyl]-1,3-benzenedicarboxamide |
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| 分子量: | 578.7 |
| 分子式: | C31H38N4O5S |
| SMILES: | CN(S(C)(=O)=O)C1=CC(C(N[C@H](C)C2=CC=CC=C2)=O)=CC(C(N[C@@H](CC3=CC=CC=C3)[C@H](O)CNC4CC4)=O)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | β-Secretase Inhibitor IV 是一种有效的具有细胞活性的BACE-1抑制剂，在 BACE-1 浓度分别为 2 nM 和 100 pM 时，IC50分别为 15.6 和 16.3 nM。 |
| IC50和靶点: | |
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Stachel, S.J., Coburn, C.A., Steele, T.G., et al.Structure-based design of potent and selective cell-permeable inhibitors of human ß-secretase (BACE-1)J. Med. Chem.47(26),6447-6450(2004)
Czvitkovich, S., Duller, S., Mathiesen, E., et al.Comparison of pharmacological modulation of APP metabolism in primary chicken telencephalic neurons and in a human neuroglioma cell lineJ. Mol. Neurosci.43(3),257-267(2011)
