Cyclobenzaprine-d
Cat. No.：YN322649
| 产品名称: | Cyclobenzaprine-d |
| CAS No.: | 82857-38-3 |
| Chemical Name: | propanedioic acid compound with 2-[(1,1-dimethylethyl)amino]-1-[[(2-methyl-1H-indol-4-yl)oxy]methyl]ethyl benzoate |
| Synonyms: | Bopindolol Malonate; Bopindolol malonate; AC1LCS45; SCHEMBL348872; CTK8F8315; HE393689; LS-120081; D01794; Sandonorm; Bopindolol hydrogen malonate; Wandonorm; Sandonorm (TN) |
| 分子量: | 484.54156 |
| 分子式: | C23H28N2O3 • C3H4O4 |
| SMILES: | O=C(O)CC(O)=O.O=C(OC(COC1=CC=CC2=C1C=C(C)N2)CNC(C)(C)C)C3=CC=CC=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Bopindolol ((±)-Bopindolol) malonate 是一种口服活性的 β-肾上腺素受体 (ARs) 拮抗剂，具有部分激动剂活性。Bopindolol malonate 对 β1-和 β2-ARs 无选择性，对 β3-AR 亚型亲和力低。Bopindolol malonate 具有内在拟交感神经和膜稳定作用，抑制肾素 (renin) 分泌，并与5-HT 受体相互作用。Bopindolol malonate 是Pindolol(HY-B0982) 的前体活性分子，可用于原发性和肾血管性高 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
van Brummelen, P., Bühler, F.R., Amann, F.W., et al.Effects of a new long-acting beta-blocker bopindolol (LT 31-200) on blood pressure, plasma catecholamines, renin and cholesterol in patients with arterial hypertensionEur. J. Pharmacol.22(6),491-493(1982)
Abiko, Y., Gotoh, H., Yokoyama, T., et al.Bopindolol and its metabolite 18-502 attenuate regional myocardial acidosis during partial occlusion of the coronary artery in dogsArch. Int. Pharmacodyn. Ther.327(1),40-45(1994)
