Treprostinil diethanolamine
Cat. No.：YN322653
| 产品名称: | Treprostinil diethanolamine |
| CAS No.: | 830354-48-8 |
| Chemical Name: | 2-[[(1R,2R,3aS,9aS)-2,3,3a,4,9,9a-hexahydro-2-hydroxy-1-[(3S)-3-hydroxyoctyl]-1H-benz[f]inden-5-yl]oxy]-acetic acid compd. with 2,2′-iminobis[ethanol], diethanolamine salt |
| Synonyms: | UT-15C |
| 分子量: | 495.7 |
| 分子式: | C23H33O5 • C4H12NO2 |
| SMILES: | O=C([O-])COC1=C(C[C@](C[C@@H](O)[C@@H]2CC[C@@H](O)CCCCC)([H])[C@]2([H])C3)C3=CC=C1.OCC[NH2+]CCO |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Treprostinil diethanolamine (UT-15C) 是一种有效的EP2、DP1和IP激动剂，对 EP2、DP1、IP、EP1、EP4、EP3 和FP的Ki值分别为 3.6、4.4、32.1、212、826、2505 和 4680 nM。Treprostinil diethanolamine 增加 cAMP 的上调，从而维持血管系统内的动态平衡。Treprostinil diethanolamine 可导致人肺动脉的血管扩张。 |
| IC50和靶点: | [{name:"IP:32.1 nM (Ki)"},{name: "FP:4680 nM (Ki)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Syed, N.I., and Jones, R.L.Assessing the agonist profiles of the prostacyclin analogues treprostinil and naxaprostene, particularly their DP₁ activityProstaglandins Leukot. Essent. Fatty Acids95,19-29(2015)
Clapp, L.H., and Gurung, R.The mechanistic basis of prostacyclin and its stable analogues in pulmonary arterial hypertension: Role of membrane versus nuclear receptorsProstaglandins Other Lipid Mediat.120,56-71(2015)
Raychauduri, B., Malur, A., Bonfield, T.L., et al.The prostacyclin analogue treprostinil blocks NFκB nuclear translocation in human alveolar macrophagesJ. Biol. Chem.277(36),33344-33348(2002)
Orie, N.N., Ledwozyw, A., Williams, D.J., et al.Differential actions of the prostacyclin analogues treprostinil and iloprost and the selexipag metabolite, MRE-269 (ACT-333679) in rat small pulmonary arteries and veinsProstaglandins Other Lipid Mediat.106,1-7(2013)
Nikam, V.S., Schermuly, R.T., Dumitrascu, R., et al.Treprostinil inhibits the recruitment of bone marrow-derived circulating fibrocytes in chronic hypoxic pulmonary hypertensionEur. Respir. J.36(6),1302-1314(2010)
