CP94253 hydrochloride
Cat. No.：YN322658
CAS No. ：845861-39-4
| 产品名称: | CP94253 hydrochloride |
| CAS No.: | 845861-39-4 |
| Chemical Name: | 5-propoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-pyrrolo[3,2-b]pyridine, monohydrochloride |
| Synonyms: | CP 94253 hydrochloride |
| 分子量: | 293.79162 |
| 分子式: | C15H19N3O • HCl |
| SMILES: | CCCOC1=CC=C2C(C(C3=CCNCC3)=CN2)=N1.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CP94253 盐酸盐是5-HT1B受体的有效和选择性激动剂(在放射性配体结合实验中，Ki=2 nM)。对 5-HT1A、5-HT1D、5-HT1C和 5-HT2受体的Ki值分别为 89、49、860 和 1600 nM。CP94253 盐酸盐在体内全身给药后具有中枢活性< |
| IC50和靶点: | |
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Koe, B.K., Nielsen, J.A., Macor, J.E., et al.Biochemical and behavioral studies of the 5-HT1B receptor agonist, CP-94,253Drug Dev. Res.26(3),241-250(1992)
Fish, E.W., Faccidomo, S., and Miczek, K.A.Aggression heightened by alcohol or social instigation in mice: Reduction by the 5-HT1B receptor agonist CP-94,253Psychopharmacology (Berl.)146(4),391-399(1999)
Tatarczyńska, E., Antkiewicz-Michaluk, L., Kłodzińska, A., et al.Antidepressant-like effect of the selective 5-HT1B receptor agonist CP 94253: A possible mechanism of actionEur. J. Pharmacol.516(1),46-50(2005)
Chojnacka-Wójcik, E., Kłodzińska, A., and Tatarczyńska, E.The anxiolytic-like effect of 5-HT1B receptor ligands in rats: A possible mechanism of actionJ. Pharm. Pharmacol.57(2),253-257(2005)
