Rolapitant hydrochloride
Cat. No.：YN322662
| 产品名称: | Rolapitant hydrochloride |
| CAS No.: | 858102-79-1 |
| Chemical Name: | (5S,8S)-8-[[[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethyl]oxy]methyl]-8-phenyl-1,7-diazaspiro[4.5]decan-2-one Hydrochloride; Sch 619734 |
| Synonyms: | 罗拉匹坦盐酸盐; SCH619734 hydrochloride |
| 分子量: | 536.94 |
| 分子式: | C25H27ClF6N2O2 |
| SMILES: | O=C1N[C@]2(CN[C@@](C3=CC=CC=C3)(CO[C@@H](C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)C)CC2)CC1.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Rolapitant (SCH619734) hydrochloride 是一种长效且具有选择性和口服活性的神经激肽 1 (NK1) 受体拮抗剂，Ki值为 0.66 nM。Rolapitant hydrochloride 不与 CYP3A4 产生互作。Rolapitant hydrochloride 在雪貂呕吐模型中显示出强效的止吐活性。 |
| IC50和靶点: | [{name:"human NK1:0.66 (Ki)"},{name: "gerbil NK1:0.13 (Ki)"},{name: "guinea pig NK1:0.72 (Ki)"},{name: "monkey NK1:2.5 (Ki)"},{name: "rabbit NK1:31.7 (Ki)"},{name: "rat NK1:78.6 (Ki)"},{name: "mouse NK1:60.4 (Ki)"}] |
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| Solvent & Solubility: |
Rojas, C. et al.: Cancer Treat. Rev., 41, 904 (2015)
Navari, R. et al.: Exp. Rev. Anticanc. Ther., 15, 1127 (2015)
