AMG 837
Cat. No.：YN322671
| 产品名称: | AMG 837 |
| CAS No.: | 865231-46-5 |
| Chemical Name: | βS-1-propyn-1-yl-4-[[4'-(trifluoromethyl)[1,1'-biphenyl]-3-yl]methoxy]-benzenepropanoic acid |
| Synonyms: | AMG-837; AMG837 |
| 分子量: | 438.4 |
| 分子式: | C26H21F3O3 |
| SMILES: | OC(C[C@H](C#CC)C(C=C1)=CC=C1OCC2=CC(C3=CC=C(C(F)(F)F)C=C3)=CC=C2)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AMG 837钠盐是GPR40激动剂，EC50为13 nM，具有较好的药代动力学表现。 |
| IC50和靶点: | |
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Houze, J.B., Zhu, L., Sun, Y., et al.AMG 837: A potent, orally bioavailable GPR40 agonistBioorg. Med. Chem. Lett22(2),1267-1270(2012)
Lin, D.C.-H., Zhang, J., Zhuang, R., et al.AMG 837: A novel GPR40/FFA1 agonist that enhances insulin secretion and lowers glucose levels in rodentsPLoS One6(11),e27270(2011)
Luo, J., Swaminath, G., Brown, S.P., et al.A potent class of GPR40 full agonists engages the enteroinsular axis to promote glucose control in rodentsPLoS One7(10),e46300(2012)
