Olodaterol
Cat. No.：YN322672
CAS No. ：868049-49-4
| 产品名称: | Olodaterol |
| CAS No.: | 868049-49-4 |
| Chemical Name: | 6-hydroxy-8-[(1R)-1-hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-2H-1,4-benzoxazin-3(4H)-one |
| Synonyms: | BI1744 |
| 分子量: | 386.4 |
| 分子式: | C21H26N2O5 |
| SMILES: | COC1=CC=C(CC(C)(C)N([H])C[C@H](O)C2=C(OCC(N3[H])=O)C3=CC(O)=C2)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Olodaterol (BI1744) 是一种选择性、长效的β2-adrenoceptor(β2-AR) 激动剂(EC50=0.1 nM；pKi= 9.14 for human β2-adrenoceptor)。 Olodaterol 可用于慢性阻塞性肺疾病 (COPD) 和肺纤维化。 |
| IC50和靶点: | [{name:"β2 adrenoceptor:.1 nM (EC50)"}] |
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Boujyssou, T., Hoenke, C., Rudolf, K., et al.Discovery of olodaterol, a novel inhaled β2-adrenoceptor agonist with a 24 h bronchodilatory efficacyBioorg. Med. Chem. Lett.20(4),1410-1414(2010)
Boyssou, T., Casarosa, P., Naline, E., et al.Pharmacological characterization of olodaterol, a novel inhaled β2-adrenoceptor agonist exerting a 24-hour-long duration of action in preclinical modelsJ. Pharmacol. Exp. Ther.334(1),53-62(2010)
Donohue, J.F.Systematic review comparing LABA, olodaterol, and indacaterol: LimitationsInt. J. Chron. Obstruct. Pulmon. Dis.9,1331-1333(2014)
