LY3027788 hydrochloride
Cat. No.：YN322674
| 产品名称: | LY3027788 hydrochloride |
| CAS No.: | 869802-58-4 |
| Chemical Name: | 9-(dimethylamino)-3-(hexahydro-1H-azepin-1-yl)-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(3H)-one |
| Synonyms: | |
| 分子量: | 343.5 |
| 分子式: | C17H21N5OS |
| SMILES: | O=C1N(N2CCCCCC2)C=NC3=C1SC4=C3C(N(C)C)=CC=N4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | A-841720 是一种有效的、非竞争性的、选择性的mGlu1受体拮抗剂，对人 mGlu1 受体的IC50为 10 nM。A-841720 的选择性是 mGlu5 的 34 倍 (IC50为 342 nM)，并且对一系列其他神经递质受体、离子通道和转运蛋白没有显着活性。A-841720 具有用于慢性疼痛研究的潜力。 |
| IC50和靶点: | [{name:"Human mGluR1:10 nM (IC50)"},{name: "human mGluR5:342 nM (IC50)"}] |
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El-Kouhen, O., Lehto, S.G., Pan, J.B., et al.Blockade of mGluR1 receptor results in analgesia and disruption of motor and cognitive performances: Effects of A-841720, a novel non-competitive mGluR1 receptor antagonistBr. J. Pharmacol.149(6),761-774(2006)
Halbout, B., Bernardi, R.E., Hansson, A.C., et al.Incubation of cocaine seeking following brief cocaine experience in mice is enhanced by mGluR1 blockadeJ. Neurosci.34(5),1781-1790(2014)
