Spiradoline mesylate
Cat. No.：YN322676
| 产品名称: | Spiradoline mesylate |
| CAS No.: | 87173-97-5 |
| Chemical Name: | rel-3,4-dichloro-N-methyl-N-[(5S,7R,8R)-7-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec-8-yl]-benzeneacetamide, monomethanesulfonate |
| Synonyms: | U-62066 mesylate |
| 分子量: | 521.49794 |
| 分子式: | C22H30Cl2N2O2 • CH3SO3H |
| SMILES: | ClC1=C(Cl)C=CC(CC(N(C)[C@H]2CC[C@]3(OCCC3)C[C@@H]2N4CCCC4)=O)=C1.CS(O)(=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Spiradoline mesylate (U-62066 mesylate) 是一种芳基乙酰胺，是一种选择性 kappa 阿片受体 (κ-opioid receptor, KOR) 激动剂，在豚鼠中的Ki为 8.6 nM。Spiradoline mesylate 对 μ 和 δ 受体的 Ki值分别为 252 nM 和 9400 nM。Spiradoline mesylate 具有强效的利尿，止痛，抗心律失常，镇咳，神经保护作用，并易于穿过血脑屏障。 |
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| Solvent & Solubility: |
Vonvoigtlander, P.F., and Lewis, R.A.Analgesic and mechanistic evaluation of spiradoline, a potent kappa opioidJ. Pharmacol. Exp. Ther.246(1),259-262(1988)
