S1RA
Cat. No.：YN380413
CAS No. ：878141-96-9
规格
价格(RMB)
库存
| 产品名称: | S1RA |
| CAS No.: | 878141-96-9 |
| Chemical Name: | 4-[2-[[5-methyl-1-(2-naphthalenyl)-1H-pyrazol-3-yl]oxy]ethyl]-morpholine |
| Synonyms: | E-52862 |
| 分子量: | 337.4 |
| 分子式: | C20H23N3O2 |
| SMILES: | CC1=CC(OCCN2CCOCC2)=NN1C3=CC(C=CC=C4)=C4C=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | S1RA(E-52862)是高活性和选择性的sigma-1受体（σ1R）拮抗剂，Ki为17nM，而对σ2R的Ki则高于1000nM。 |
| IC50和靶点: | |
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Romero, L., Zamanillo, D., Nadal, X., et al.Pharmacological properties of S1RA, a new sigma-1 receptor antagonist that inhibits neuropathic pain and activity-induced spinal sensitizationBr. J. Pharmacol.166(8),2289-2306(2012)
Sánchez-Fernández, C., Montilla-García, Á., González-Cano, R., et al.Modulation of peripheral μ-opioid analgesia by σ1 receptorsJ. Pharmacol. Exp. Ther.348(1),32-45(2014)
