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Naloxonazine dihydrochloride

Cat. No.:YN322683

  • CAS No. :880759-65-9

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    • 参考文献
    • 产品名称: Naloxonazine dihydrochloride
      CAS No.: 880759-65-9
      Chemical Name: (5α)-[(5α)-4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-ylidene]hydrazone, 4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-morphinan-6-one, dihydrochloride
      Synonyms:
      分子量:723.7
      分子式:C38H42N4O6 • 2HCl
      SMILES:O[C@]12[C@]3(CCN(CC=C)[C@@H]2C4)[C@](OC5=C3C4=CC=C5O)([H])/C(CC1)=N/N=C(CC[C@@]6(O)[C@H]7CC8=CC=C9O)/[C@@]%10([H])[C@]6(CCN7CC=C)C8=C9O%10.Cl.Cl
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Naloxonazine dihydrochloride 是一种特异性的μ-opioid receptor拮抗剂,IC50为 5.4 nM。Naloxonazine dihydrochloride 也具有抗利什曼原虫活性。
      IC50和靶点: [{name:"μ Opioid Receptor/MOR:5.4 nM (IC50)"}]
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Raynor, K., Kong, H., Chen, Y., et al.Pharmacological characterization of the cloned κ-, δ-, and μ-opioid receptorsMol. Pharm.45(2),330-334(1994)

      Cruciani, R.A., Lutz, R.A., Munson, P.J., et al.Naloxonazine effects on the interaction of enkephalin analogs with mu-1, mu and delta opioid binding sites in rat brain membranesJ. Pharmacol. Exp. Ther.242(1),15-20(1987)

      Verborgh, C., and Meert, T.F.Antagonistic effects of naloxone and naloxonazine on sufentanil-induced antinociception and respiratory depression in ratsPain83(1),17-24(1999)

      Mhatre, M., and Holloway, F.μ1-opioid antagonist naloxonazine alters ethanol discrimination and consumptionAlcohol29(2),109-116(2003)

      Rademacher, D.J., and Steinpreis, R.E.Effects of the selective μ1-opioid receptor antagonist, naloxonazine, on cocaine-induced conditioned place preference and locomotor behavior in ratsNeurosci. Lett.332(3),159-162(2002)

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