INCB 3284 dimesylate
Cat. No.：YN322685
| 产品名称: | INCB 3284 dimesylate |
| CAS No.: | 887401-93-6 |
| Chemical Name: | N-[2-[[(3R)-1-[trans-4-hydroxy-4-(6-methoxy-3-pyridinyl)cyclohexyl]-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)-benzamide, dimethanesulfonate |
| Synonyms: | INCB3284; INCB 3284; INCB-3284; INCB3284 mesylate; INCB3284 dimesylate. |
| 分子量: | 712.8 |
| 分子式: | C26H31F3N4O4 • 2CH3SO3H |
| SMILES: | O[C@]1(C2=CN=C(OC)C=C2)CC[C@@H](N3C[C@H](NC(CNC(C4=CC(C(F)(F)F)=CC=C4)=O)=O)CC3)CC1.CS(=O)(O)=O.CS(=O)(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | INCB 3284 dimesylate 是一种有效的，选择性的人CCR2拮抗剂，能够抑制单核细胞趋化蛋白 1 与hCCR2结合，IC50值为 3.7 nM。INCB 3284 dimesylate 可用于急性肝功能衰竭的研究。 |
| IC50和靶点: | [{name:"MCP-1-hCCR2:3.7 nM (IC50)"}] |
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| Solvent & Solubility: |
Xue, C.B., Feng, H., Cao, G., et al.Discovery of INCB3284, a potent, selective, and orally bioavailable hCCR2 antagonistACS Med. Chem. Lett.2,450-454(2011)
