LPA1 receptor antagonist 1
Cat. No.：YN322688
| 产品名称: | LPA1 receptor antagonist 1 |
| CAS No.: | 891859-12-4 |
| Chemical Name: | 1-[[3,4-dihydro-6-[(2-methoxy-4-propylphenyl)methoxy]-1-methyl-2-naphthalenyl]methyl]-3-azetidinecarboxylic acid |
| Synonyms: | ONO-4641 |
| 分子量: | 435.6 |
| 分子式: | C27H33NO4 |
| SMILES: | CCCC1=CC=C(COC2=CC(CCC(CN3CC(C(O)=O)C3)=C4C)=C4C=C2)C(OC)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ceralifimod (ONO-4641) 是 1-磷酸鞘氨醇受体 1 和 5 (S1P1andS1P5) 的强效选择性激动剂，其对人 S1P1和 S1P5的EC50值分别为 27.3，334 pM。 |
| IC50和靶点: | |
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Kurata, H., Kusumi, K., Otsuki, K., et al.Discovery of a 1-methyl-3,4-dihydronaphthalene-based sphingosine-1-phosphate (S1P) receptor agonist ceralifimod (ONO-4641). A S1P1 and S1P5 selective agonist for the treatment of autoimmune diseaseJ. Med. Chem.60(23),9508-9530(2017)
Komiya, T., Sato, K., Shioya, H., et al.Efficacy and immunomodulatory actions of ONO-4641, a novel selective agonist for sphingosine 1-phosphate receptors 1 and 5, in preclinical models of multiple sclerosisClin. Exp. Immunol.171(1),54-62(2013)
