CAY10595
Cat. No.：YN322696
| 产品名称: | CAY10595 |
| CAS No.: | 916047-16-0 |
| Chemical Name: | 5-chloro-1'-[5-chloro-2-fluorophenyl)methyl]-2,2',5'-trioxo-spiro[3H-indole-3,3'pyrrolidine]-1(2H)-acetic acid |
| Synonyms: | |
| 分子量: | 451.2 |
| 分子式: | C20H13Cl2FN2O5 |
| SMILES: | ClC1=CC=C(N(CC(O)=O)C(C23CC(N(CC4=C(F)C=CC(Cl)=C4)C3=O)=O)=O)C2=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CAY10595 是有效的前列腺素 D2 受体(CRTH2/DP2)的拮抗剂，其对人类的Ki值为 10 nM。 |
| IC50和靶点: | [{name:"DP:10 nM (Ki)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Hirai, H., Tanaka, K., Yoshie, O., et al.Prostaglandin D2 selectivity induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2J. Exp. Med.193(2),255-261(2001)
Crosignani, S., Page, P., Missotten, M., et al.Discovery of a new class of potent, selective, and orally bioavailable CRTH2 (DP2) receptor antagonists for the treatment of allergic inflammatory diseasesJ. Med. Chem.51(7),2227-2243(2008)
