ABP688
Cat. No.：YN322700
CAS No. ：924298-51-1
| 产品名称: | ABP688 |
| CAS No.: | 924298-51-1 |
| Chemical Name: | 3-[2-(6-methyl-2-pyridinyl)ethynyl]-2-cyclohexen-1-one, O-methyloxime |
| Synonyms: | |
| 分子量: | 240.30042 |
| 分子式: | C15H16N2O |
| SMILES: | CC1=CC=CC(C#CC(CCC/2)=CC2=N\OC)=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ABP688 是一种高亲和力的人源 mGlu5 受体拮抗剂，其Ki为 1.7 nM。放射性同位素标记的 ABP688 可作为 PET 示踪剂用于 mGlu5 受体的临床成像 。 |
| IC50和靶点: | [{name:"human mGluR5:1.7 nM (Ki)"}] |
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| Clinical Trial: | |
| Solvent & Solubility: |
Hintermann, S., Vranesic, I., Allgeier, H., et al.ABP688, a novel selective and high affinity ligand for the labeling of mGlu5 receptors: Identification, in vitro pharmacology, pharmacokinetic and biodistribution studiesBioorg. Med. Chem.15(2),903-914(2007)
Elmenhorst, D., Minuzzi, L., Aliaga, A., et al.In vivo and in vitro validation of reference tissue models for the mGluR5 ligand [11C]ABP688J. Cereb. Blood Flow Metab.30(8),1538-1549(2010)
