ML191
Cat. No.：YN322705
CAS No. ：931695-79-3
| 产品名称: | ML191 |
| CAS No.: | 931695-79-3 |
| Chemical Name: | 5-phenyl-3-(1-(1-(p-tolyl)cyclopropane-1-carbonyl)piperidin-4-yl)-1,3,4-oxadiazol-2(3H)-one |
| Synonyms: | CID23612552 |
| 分子量: | 403.5 |
| 分子式: | C24H25N3O3 |
| SMILES: | CC1=CC=C(C2(CC2)C(N3CCC(N4N=C(C5=CC=CC=C5)OC4=O)CC3)=O)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ML-191 是GPR55的拮抗剂。它抑制溶血磷脂酰肌醇诱导的GPR55信号传导（在过度表达GPR55的 U2OS 细胞中EC50=1.076 µM）。ML-191 抑制 LPI 诱导的 ERK1/2 磷酸化 (IC50=328 nM) 。当使用浓度为 30 µM 时，ML-191 抑制 PKCβII 的受体依赖性易位。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Heynen-Genel, S., Dahl, R., Shi, S., et al.Selective GPR55 antagonists: Screening for selective ligands for GPR55Probe Reports from the NIH Molecular Libraries Program,(2011)
