Cicaprost
Cat. No.：YN322707
| 产品名称: | Cicaprost |
| CAS No.: | 94079-80-8 |
| Chemical Name: | 2-[2-[(2E,3aS,4S,5R,6aS)-hexahydro-5-hydroxy-4-[(3S,4S)-3-hydroxy-4-methyl-1,6-nonadiyn-1-yl]-2(1H)-pentalenylidene]ethoxy]-acetic acid |
| Synonyms: | ZK 96480 |
| 分子量: | 374.5 |
| 分子式: | C22H30O5 |
| SMILES: | O[C@@H]1C[C@H](C/2)[C@H](CC2=C\COCC(O)=O)[C@H]1C#C[C@@H](O)[C@@H](C)CC#CCC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Cicaprost (ZK 96480) 是一种前列环素受体 (IP) 激动剂。Cicaprost可引起动脉的浓度依赖性舒张，EC50为 5.8 nM 。 |
| IC50和靶点: | |
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Kiriyama, M., Ushikubi, F., Kobayashi, T., et al.Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cellsBr. J. Pharmacol.122(2),217-224(1997)
Hildebrand, M., Staks, T., and Nieuweboer, B.Pharmacokinetics and pharmacodynamics of cicaprost in healthy volunteers after oral administration of 5 to 20 microgramsEur. J. Clin. Pharmacol.39(2),149-153(1990)
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Schirner, M., Kraus, C., Lichtner, R.B., et al.Tumor metastasis inhibition with the prostacyclin analogue cicaprost depends on discontinuous plasma peak levelsProstaglandins Leukot. Essent. Fatty Acids58(4),311-317(1998)
