GAT228
Cat. No.：YN322709
| 产品名称: | GAT228 |
| CAS No.: | 944154-76-1 |
| Chemical Name: | 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(3-pyridinylmethyl)-1H-pyrazole-3-carboxamide |
| Synonyms: | |
| 分子量: | 471.8 |
| 分子式: | C23H17Cl3N4O |
| SMILES: | CC1=C(C2=CC=C(Cl)C=C2)N(C3=CC=C(Cl)C=C3Cl)N=C1C(NCC4=CC=CN=C4)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MJ15 是一种有效且选择性的CB1受体拮抗剂，对于大鼠CB1受体，其Ki为 27.2 pM，IC50为 118.9 pM。MJ15 在肥胖和高脂血症模型中表现出效力，可抑制饮食诱导肥胖的大鼠和小鼠的食物摄入和体重增加。 |
| IC50和靶点: | [{name:"rCB1-R:27.2 pM (Ki)"},{name: "rCB1-R:118.9 pM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Chen, W., Tang, H., Liu, H., et al.Novel selective antagonist of the cannabinoid CB1 receptor, MJ15, with prominent anti-obesity effect in rodent modelsEur. J. Pharmacol.637(1-3),178-185(2010)
