Eticlopride hydrochloride
Cat. No.：YN322719
| 产品名称: | Eticlopride hydrochloride |
| CAS No.: | 97612-24-3 |
| Chemical Name: | 3-chloro-5-ethyl-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-6-hydroxy-2-methoxy-benzamide, monohydrochloride |
| Synonyms: | FLB 131; FLB131; FLB-131; Eticlopride |
| 分子量: | 377.30542 |
| 分子式: | C17H25ClN2O3 • HCl |
| SMILES: | CCC1=CC(Cl)=C(OC)C(C(NC[C@H]2N(CC)CCC2)=O)=C1O.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Eticlopride hydrochloride 是一种选择性多巴胺 D2 样受体拮抗剂，对多巴胺 D2、α1-肾上腺素能、α2-肾上腺素能、5HT1、5HT2 受体具有高亲和力，Ki分别为 0.09、112、699、6220 和 830 nM。具有抗精神病作用。 |
| IC50和靶点: | [{name:"D2 Receptor:0.09 nM (Ki)"}] |
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Tang, L., Todd, R.D., Heller, A., et al.Pharmacological and functional characterization of D2, D3 and D4 dopamine receptors in fibroblast and dopaminergic cell linesJ. Pharmacol. Exp. Ther.268(1),495-502(1994)
Hall, H., Köhler, C., and Gawell, L.Some in vitro receptor binding properties of [3H]eticlopride, a novel substituted benzamide, selective for dopamine-D2 receptors in the rat brainEur. J. Pharmacol.111(2),191-199(1985)
Giuliani, D., and Ferrari, F.Involvement of dopamine receptors in the antipsychotic profile of (–) eticlopridePhysiol. Behav.61(4),563-567(1997)
