NUCC-390 dihydrochloride
Cat. No.：YN322832
CAS No. ：2749281-71-6
| 产品名称: | NUCC-390 dihydrochloride |
| CAS No.: | 2749281-71-6 |
| Chemical Name: | 1-piperidinyl[4,5,6,7-tetrahydro-1-propyl-5-[[2-(4-pyridinyl)ethyl]amino]-1H-indazol-3-yl]-methanone, dihydrochloride |
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| 分子量: | 468.4625 |
| 分子式: | C23H33N5O • 2HCl |
| SMILES: | CCCN1N=C(C(N2CCCCC2)=O)C3=C1CCC(C3)NCCC4=CC=NC=C4.Cl.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NUCC-390 dihydrochloride 是新型的选择性小分子CXCR4receptor受体激动剂。NUCC-390 dihydrochloride 可以诱导CXCR4受体的内化，作用方式与 AMD3100 (HY-10046) 相反。NUCC-390 dihydrochloride 在动物模型中，有助于神经退行性变后神经功能恢复。 |
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Mishra, R.K., Shum, A.K., Platanias, L.C., et al.Discovery and characterization of novel small-molecule CXCR4 receptor agonists and antagonistsSci. Rep.6:30155,1-9(2016)
Zanetti, G., Negro, S., Megighian, A., et al.A CXCR4 receptor agonist strongly stimulates axonal regeneration after damageAnn. Clin. Transl. Neurol.6(12),2395-2402(2019)
Stazi, M., D'Este, G., Mattarei, A., et al.An agonist of the CXCR4 receptor accelerates the recovery from the peripheral neuroparalysis induced by Taipan snake envenomationPLoS Negl. Trop. Dis.14(9),e0008547(2020)
