Phenserine
Cat. No.：YN380023
| 产品名称: | Phenserine |
| CAS No.: | 101246-66-6 |
| Chemical Name: | (3aS,8aR)-5-(N-phenylcarbamate)1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-pyrrolo[2,3-b]indol-5-ol |
| Synonyms: | (-)-Eseroline phenylcarbamate; (-) |
| 分子量: | 337.42 |
| 分子式: | C₂₀H₂₃N₃O₂ |
| SMILES: | CN1[C@](N(C)CC2)([H])[C@]2(C)C3=C1C=CC(OC(NC4=CC=CC=C4)=O)=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Phenserine ((-)-Eseroline phenylcarbamate) 是 Physostigmine 的衍生物，是一种有效的，非竞争性，长效和选择性的AChE抑制剂。Phenserine 可减少 β-淀粉样蛋白前体蛋白 (APP) 和 β-淀粉样肽 (Aβ) 的形成。Phenserine 可改善认知能力并减轻阿尔茨海默氏病的进展。 |
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Yu, Q.S., Zhu, X., Holloway, H.W., et al.Anticholinesterase activity of compounds related to geneserine tautomers. N-oxides and 1,2-oxazinesJ. Med. Chem.45(17),3684-3691(2002)
Luo, W., Yu, Q.S., Kulkarni, S.S., et al.Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepineJ. Med. Chem.49(7),2174-2185(2006)
Utsuki, T., Yu, Q.-s., Davidson, D., et al.Identification of novel small molecule inhibitors of amyloid precursor protein synthesis as a route to lower Alzheimer's disease amyloid-β peptideJ. Pharmacol. Exp. Ther.318(2),855-862(2006)
