Donepezil
Cat. No.：YN380101
CAS No. ：120014-06-4
| 产品名称: | Donepezil |
| CAS No.: | 120014-06-4 |
| Chemical Name: | 2,3-dihydro-5,6-dimethoxy-2[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one |
| Synonyms: | 多奈哌齐; E2020 free base |
| 分子量: | 379.49 |
| 分子式: | C₂₄H₂₉NO₃ |
| SMILES: | O=C(C(C=C(OC)C(OC)=C1)=C1C2)C2CC(CC3)CCN3CC4=CC=CC=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Donepezil (E2020 free base) 是AChE抑制剂，对牛 AChE 和人 AChE 的IC50分别为 8.12 nM 和 11.6 nM。 |
| IC50和靶点: | |
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Cacabelos, R.Donepezil in Alzheimer's disease: From conventional trials to pharmacogeneticsNeuropsychiatr. Dis. Treat.3(3),303-333(2007)
Kim, H.G., Moon, M., Choi, J.G., et al.Donepezil inhibits the amyloid-beta oligomer-induced microglial activation in vitro and in vivoNeurotoxicology40,23-32(2014)
Scali, C., Casamenti, F., Bellucci, A., et al.Effect of subchronic administration of metrifonate, rivastigmine and donepezil on brain acetylcholine in aged F344 ratsJ. Neural Transm. (Vienna)109(7-8),1067-1080(2002)
