(-)-Huperzine A
Cat. No.：YN380120
CAS No. ：102518-79-6
| 产品名称: | (-)-Huperzine A |
| CAS No.: | 102518-79-6 |
| Chemical Name: | (5R,9R,11E)-5-amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-5,9-methanocycloocta[b]pyridin-2(1H)-one |
| Synonyms: | 石杉碱甲; Huperzine A |
| 分子量: | 242.32 |
| 分子式: | C₁₅H₁₈N₂O |
| SMILES: | O=C1NC2=C([C@@](/C3=C\C)(N)CC(C)=C[C@@]3([H])C2)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | (-)-Huperzine A (Huperzine A) 是从中国梅花苔中分离得到的生物碱，具有神经保护活性。(-)-Huperzine A 是一种高效、高特异性、可逆的，具有血脑屏障渗透性的乙酰胆碱酯酶 (AChE) 抑制剂， 其IC50值为 82 nM。 (-)-Huperzine A 也N-甲基-D-天冬氨酸 (NMDA) 受体的非竞争性拮抗剂。(-)-Huperzine A 被开发用于神经退行性疾病的研究，包括阿尔茨海默病。 |
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Tun, M.K.M., and Herzon, S.B.The pharmacology and therapeutic potential of (-)-huperzine AJ. Exp. Pharmacol.4,113-123(2012)
Yang, G., Wang, Y., Tian, J., et al.Huperzine A for Alzheimer's disease: A systematic review and meta-analysis of randomized clinical trialsPLoS One8(9),(2013)
