Galanthamine
Cat. No.：YN380149
| 产品名称: | Galanthamine |
| CAS No.: | 357-70-0 |
| Chemical Name: | (4aS,6R,8aS)-4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol |
| Synonyms: | 加兰他敏; Galantamine |
| 分子量: | 287.35 |
| 分子式: | C₁₇H₂₁NO₃ |
| SMILES: | O[C@@H]1C[C@@H]2OC3=C4C(CN(C)CC[C@]42C=C1)=CC=C3OC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Galanthamine 是一种有效的乙酰胆碱酯酶 (AChE) 抑制剂，IC50为 500 nM。 |
| IC50和靶点: | |
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Harvey, A.L.The pharmacology of galanthamine and its analoguesPharmacol. Ther.68(1),113-128(1995)
Rook, Y., Schmidtke, K.U., Gaube, F., et al.Bivalent β-carbolines as potential multitarget anti-Alzheimer agentsJ. Med. Chem.53(9),3611-3617(2010)
Samochocki, M., Zerlin, M., Jostock, R., et al.Galantamine is an allosterically potentiating ligand of the human α4/β2 nAChRActa Neurol. Scand. Suppl.176,68-73(2000)
Van Dam, D., and De Deyn, P.P.Cognitive evaluation of disease-modifying efficacy of galantamine and memantine in the APP23 modelEur. Neuropsychopharmacol.16(1),59-69(2006)
