Epiberberine
Cat. No.：YN380223
| 产品名称: | Epiberberine |
| CAS No.: | 6873-09-2 |
| Chemical Name: | 11,12-dihydro-8,9-dimethoxy-benzo[a]-1,3-benzodioxolo[4,5-g]quinolizinium |
| Synonyms: | 表小檗碱 |
| 分子量: | 336.36 |
| 分子式: | C₂₀H₁₈NO₄+ |
| SMILES: | COC1=C(OC)C=C2C(CC[N+]3=C2C=C(C=C4)C(C5=C4OCO5)=C3)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Epiberberine 是从黄连中得到的生物碱，为有效的AChE和BChE抑制剂，和非竞争性的BACE1抑制剂，IC50值分别为 1.07，6.03 和 8.55 μM。Epiberberine 具有抗氧化作用，能够清除 ONOO-(IC50，16.83 μM)，可用于阿尔滋海默症和糖尿病的研究。在 3T3-L1 细胞分化早期，Epiberberine 能够下调 Raf/MEK1/2/ERK1/2 和 AMPKα/Akt 信号通路。 |
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Jung, H.A., Min, B.S., Yokozawa, T., et al.Anti-Alzheimer and antioxidant activities of Coptidis Rhizoma alkaloidsBiol. Pharm. Bull.32(8),1433-1438(2009)
Chen, H.-Y., Ye, X.-L., Cui, X.-L., et al.Cytotoxicity and antihyperglycemic effect of minor constituents from Rhizoma Coptis in HepG2 cellsFitoterapia83(1),67-73(2012)
Zou, Z.-Y., Hu, Y.-R., Ma, H., et al.Epiberberine reduces serum cholesterol in diet-induced dyslipidemia Syrian golden hamsters via network pathways involving cholesterol metabolismEur. J. Pharmacol.774,(2016)
