Timosaponin AIII
Cat. No.：YN380235
| 产品名称: | Timosaponin AIII |
| CAS No.: | 41059-79-4 |
| Chemical Name: | (3β,5β,25S)-spirostan-3-yl 2-O-β-D-glucopyranosyl-β-D-galactopyranoside |
| Synonyms: | Filiferin B,Timosaponin A3,知母皂苷 A-III,AneMarsaponin A3 |
| 分子量: | 740.92 |
| 分子式: | C₃₉H₆₄O₁₃ |
| SMILES: | C[C@@]12[C@]([C@@H]3C)([H])[C@](O[C@]34CC[C@H](C)CO4)([H])C[C@@]1([H])[C@@](CC[C@@]5([H])[C@@]6(CC[C@H](O[C@@](O[C@H](CO)[C@H](O)[C@@H]7O)([H])[C@@H]7O[C@]([C@@H]([C@@H](O)[C@@H]8O)O)([H])O[C@@H]8CO)C5)C)([H])[C@]6([H])CC2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Timosaponin AIII 能够抑制 乙酰胆碱酯酶(AChE)的活性，其IC50值为 35.4 μM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Lee, B., Jung, K., and Kim, D.H.Timosaponin AIII, a saponin isolated from Anemarrhena asphodeloides, ameliorates learning and memory deficits in mice.Pharmacol. Biochem. Behav.93(2),121-127(2009)
Lim, S.M., Jeong, J.J., Kang, G.D., et al.Timosaponin AIII and its metabolite sarsasapogenin ameliorate colitis in mice by inhibiting NF-κB and MAPK activation and restoring Th17/Treg cell balance.Int. Immunopharmacol.25(2),493-503(2015)
Cong, Y., Wang, L., Peng, R., et al.Timosaponin AIII induces antiplatelet and antithrombotic activity via Gq-mediated signaling by the thromboxane A2 receptorSci. Rep.6,38757(2016)
Kim, K.M., Im, A.-R., Kim, S.H., et al.Timosaponin AIII inhibits melanoma cell migration by suppressing COX-2 and in vivo tumor metastasis.Cancer Sci.107(2),181-188(2016)
Tsai, C.-H., Yang, C.-W., Wang, J.-Y., et al.Timosaponin AIII suppresses hepatocyte growth factor-induced invasive activity through sustained ERK activation in breast cancer MDA-MB-231 cells.Evid. Based Complement. Altnernat. Med.2013,421051(2013)
