Nodakenin
Cat. No.：YN380236
| 产品名称: | Nodakenin |
| CAS No.: | 495-31-8 |
| Chemical Name: | (2R)-2-[1-(β-D-glucopyranosyloxy)-1-methylethyl]-2,3-dihydro-7H-furo[3,2-g][1]benzopyran-7-one |
| Synonyms: | 紫花前胡苷 |
| 分子量: | 408.40 |
| 分子式: | C₂₀H₂₄O₉ |
| SMILES: | CC(C)([C@H]1CC2=CC(C=CC3=O)=C(O3)C=C2O1)O[C@@H]([C@@H]([C@@H](O)[C@@H]4O)O)O[C@@H]4CO |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Nodakenin 是Peucedanum decursivum Maxim根中的主要香豆素苷。Nodakenin 抑制乙酰胆碱酯酶(AChE)活性，IC50为 84.7 μM。 |
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Junzo, A.The constitution of nodakenin, a new glucoside from Peucedanum decursivum Maxim.Bull. Chem. Soc. Jpn.4(1),16-20(1929)
Rim, H.K., Cho, W., Sung, S.H., et al.Nodakenin suppresses lipopolysaccharide-induced inflammatory responses in macrophage cells by inhibiting tumor necrosis factor receptor-associated factor 6 and nuclear factor-κB pathways and protects mice from lethal endotoxin shockJ. Pharmacol. Exp. Ther.342(3),654-664(2012)
Xiong, Y., Wang, J., Yu, H., et al.The effects of nodakenin on airway inflammation, hyper-responsiveness and remodeling in a murine model of allergic asthmaImmunopharmacol. Immunotoxicol.36(5),341-348(2014)
Kang, S.Y., and Kim, Y.C.Neuroprotective coumarins from the root of Angelica gigas: Structure-activity relationshipsArch. Pharm. Res.30(11),1368-1373(2007)
Gao, Q., Jeon, S.J., Jung, H.A., et al.Nodakenin enhances cognitive function and adult hippocampal neurogenesis in miceNeurochem. Res.40(7),1438-1447(2015)
