Corynoline
Cat. No.：YN380237
| 产品名称: | Corynoline |
| CAS No.: | 18797-79-0 |
| Chemical Name: | (5bR,6S,12bR)-5b,6,7,12b,13,14-hexahydro-5b,13-dimethyl-[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridin-6-ol |
| Synonyms: | 紫蓳灵 |
| 分子量: | 367.40 |
| 分子式: | C₂₁H₂₁NO₅ |
| SMILES: | C[C@@]1(C(C=CC2=C3OCO2)=C3CN4C)[C@@]4([H])C(C=C(OCO5)C5=C6)=C6C[C@@H]1O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Corynoline，可从Corydalis incise(Papaveraceae) 中分离，是一种可逆和非竞争性的乙酰胆碱酯酶 (AChE) 抑制剂，IC50为 30.6 μM。Corynoline 通过激活Nrf2发挥抗炎作用。 |
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Kim, D.K.Inhibitory effect of corynoline isolated from the aerial parts of Corydalis incisa on the acetylcholinesteraseArch. Pharm. Res.25(6),817-819(2002)
Chlebek, J., Simone, A.D., Hošt'álková, A., et al.Application of BACE1 immobilized enzyme reactor for the characterization of multifunctional alkaloids from Corydalis cava (Fumariaceae) as Alzheimer's disease targetsFitoterapia109,241-247(2016)
Liu, B., Su, K., Wang, J., et al.Corynoline exhibits anti-inflammatory effects in lipopolysaccharide (LPS)-stimulated human umbilical vein endothelial cells through activating Nrf2Inflammation41(5),1640-1647(2018)
He, Z.-B., Chen, P., Peng, Z.-Y., et al.Effect of corynoline isolated from Corydalis bungeana turcz on lipopolysaccharides-induced sepsis in vivo and in vitroTrop. J. Pharm. Res.13(1),81-86(2014)
Yi, C., Li, X., Chen, S., et al.Natural product corynoline suppresses melanoma cell growth through inducing oxidative stressPhytother. Res.,(2020)
