Obidoxime dichloride
Cat. No.：YN380314
CAS No. ：114-90-9
| 产品名称: | Obidoxime dichloride |
| CAS No.: | 114-90-9 |
| Chemical Name: | 1,1′-[oxybis(methylene)]bis[4-[(hydroxyimino)methyl]-pyridinium, dichloride |
| Synonyms: | Pyridinium,1,1'-[oxybis(methylene)]bis[4-[(hydroxyimino)methyl]-, chloride (1:2);OBIDOXIME CHLORIDE;OBIDOXIME CHLORIDE,OFF-WHITE SOLID;oxo-[[1-[[4-(oxoazaniumylmethylidene)pyridin-1-yl]methoxymethyl]pyridin-4-ylidene]methyl]azanium,dichloride;1,1′-(Oxydim |
| 分子量: | 359.21 |
| 分子式: | C₁₄H₁₆Cl₂N₄O₃ |
| SMILES: | O/N=C/C1=CC=[N+](C=C1)COC[N+]2=CC=C(C=C2)/C=N/O.[Cl-].[Cl-] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Obidoxime dichloride 是一种非全谱肟试剂，可作为有机磷类神经毒剂中毒的解毒剂。Obidoxime dichloride 可活化被沙林蛋白抑制的乙酰胆碱酯酶 (AChE)，降低沙林蛋白的急性毒性。 |
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Kuhnen, H.Activating and inhibitory effects of bispyridinium compounds on bovine red cell acetylcholinesteraseToxicol. Appl. Pharmacol.20(1),97-104(1971)
Kassa, J., Karasova, J., Musilek, K., et al.An evaluation of therapeutic and reactivating effects of newly developed oximes (K156, K203) and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and miceToxicology243(3),311-316(2008)
Krishnan, J.K.S., Arun, P., Appu, A.P., et al.Intranasal delivery of obidoxime to the brain prevents mortality and CNS damage from organophosphate poisoningNeurotoxicology53,64-73(2016)
