NVP-TAE 684
Cat. No.：YN440051
CAS No. ：761439-42-3
规格
价格(RMB)
库存
| 产品名称: | NVP-TAE 684 |
| CAS No.: | 761439-42-3 |
| Chemical Name: | 5-chloro-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-2,4-pyrimidinediamine |
| Synonyms: | TAE 684 |
| 分子量: | 614.20 |
| 分子式: | C₃₀H₄₀ClN₇O₃S |
| SMILES: | O=S(C1=CC=CC=C1NC2=NC(NC3=CC=C(N4CCC(N5CCN(CC5)C)CC4)C=C3OC)=NC=C2Cl)(C(C)C)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NVP-TAE 684 (TAE 684) 是一种高效的，选择性的ALK抑制剂，阻止 ALCL 衍生的 ALK 依赖性细胞株的生长，IC50值为 2-10 nM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Galkin, A.V., Melnick, J.S., Kim, S., et al.Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALKProc. Natl. Acad. Sci. USA104(1),270-275(2007)
Hasan, M.K., Nafady, A., Takatori, A., et al.ALK is a MYCN target gene and regulates cell migration and invasion in neuroblastomaSci. Rep.3,(2013)
Zhang, J., Deng, X., Choi, H.G., et al.Characterization of TAE684 as a potent LRRK2 kinase inhibitorBioorg. Med. Chem. Lett.22(55),1864-1869(2012)
