A 83-01
Cat. No.：YN440094
CAS No. ：909910-43-6
规格
价格(RMB)
库存
| 产品名称: | A 83-01 |
| CAS No.: | 909910-43-6 |
| Chemical Name: | 3-(6-methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide |
| Synonyms: | ALK5 Inhibitor IV |
| 分子量: | 421.52 |
| 分子式: | C₂₅H₁₉N₅S |
| SMILES: | S=C(N1N=C(C2=NC(C)=CC=C2)C(C3=CC=NC4=CC=CC=C34)=C1)NC5=CC=CC=C5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | A 83-01 是一种有效的TGF-βI 型受体ALK5，ALK4和ALK7的抑制剂，能够抑制ALK5，ALK4和ALK7诱导的转录，IC50值分别为 12 nM，45 nM 和 7.5 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Tojo, M., Hamashima, Y., Hanyu, A., et al.The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-βCancer Sci.96(11),791-800(2005)
Cao, N., Huang, Y., Zheng, J., et al.Conversion of human fibroblasts into functional cardiomyocytes by small moleculesScience352(6290),1216-1220(2016)
Zhang, M., Lin, Y.H., Sun, Y.J., et al.Pharmacological reprogramming of fibroblasts into neural stem cells by signaling-directed transcriptional activationCell Stem Cell18(5),653-667(2016)
