Brigatinib
Cat. No.：YN440226
CAS No. ：1197953-54-0
规格
价格(RMB)
库存
| 产品名称: | Brigatinib |
| CAS No.: | 1197953-54-0 |
| Chemical Name: | 5-chloro-N4-[2-(dimethylphosphinyl)phenyl]-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-2,4-pyrimidinediamine |
| Synonyms: | 布格替尼; AP-26113 |
| 分子量: | 584.09 |
| 分子式: | C₂₉H₃₉ClN₇O₂P |
| SMILES: | CN1CCN(C2CCN(C3=CC=C(NC4=NC=C(Cl)C(NC5=CC=CC=C5P(C)(C)=O)=N4)C(OC)=C3)CC2)CC1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Brigatinib (AP-26113) 是有效，选择性的ALK抑制剂，IC50值为 0.6 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Ceccon, M., Mologni, L., Bisson, W., et al.Crizotinib-resistant NPM-ALK mutants confer differential sensitivity to unrelated Alk inhibitorsMol. Cancer Res.11(2),122-132(2013)
Katayama, R., Khan, T.M., Benes, C., et al.Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALKProc. Natl. Acad. Sci. USA108(18),7535-7540(2011)
Siaw, J.T., Wan, H., Pfeifer, K., et al.Brigatinib, an anaplastic lymphoma kinase inhibitor, abrogates activity and growth in ALK-positive neuroblastoma cells, Drosophila and miceOncotarget7(20),29011-29022(2016)
