Alectinib Hydrochloride
Cat. No.：YN440238
CAS No. ：1256589-74-8
规格
价格(RMB)
库存
| 产品名称: | Alectinib Hydrochloride |
| CAS No.: | 1256589-74-8 |
| Chemical Name: | 9-Ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-5H-Benzo[b]carbazole-3-carbonitrile Hydrochloride; |
| Synonyms: | 艾乐替尼盐酸盐; CH5424802 Hydrochloride; RO5424802 Hydrochloride; AF-802 Hydrochloride |
| 分子量: | 519.08 |
| 分子式: | C₃₀H₃₅ClN₄O₂ |
| SMILES: | [H]Cl.N#CC1=CC2=C(C3=C(N2)C(C)(C4=CC(N5CCC(CC5)N6CCOCC6)=C(C=C4C3=O)CC)C)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Alectinib Hydrochloride (CH5424802 Hydrochloride; RO5424802 Hydrochloride; AF-802 Hydrochloride) 是一种有效，选择性和口服的ALK抑制剂，其IC50为 1.9 nM，Kd值为 2.4 nM (以 ATP 竞争方式)，并且还抑制ALK F1174L和ALK R1275Q，其IC50分别为 1 nM 和 3.5 nM。Alectinib Hydrochloride 还具有有效的中枢神经系统 (CNS) 渗透能力。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Sakamoto, H., et al.: Cancer Cell., 19, 679 (2011)
Kinoshita, K., et al.: Bio-org. Medn., 20, 1271 (2012)
