GSK1838705A
Cat. No.：YN440240
CAS No. ：1116235-97-2
规格
价格(RMB)
库存
| 产品名称: | GSK1838705A |
| CAS No.: | 1116235-97-2 |
| Chemical Name: | 2-[[2-[[1-[2-(dimethylamino)acetyl]-2,3-dihydro-5-methoxy-1H-indol-6-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]-6-fluoro-N-methyl-benzamide |
| Synonyms: | GSK1838705A; GSK-1838705A; GSK 1838705A. |
| 分子量: | 532.57 |
| 分子式: | C₂₇H₂₉FN₈O₃ |
| SMILES: | FC1=C(C(NC)=O)C(NC2=C3C(NC=C3)=NC(NC4=CC5=C(CCN5C(CN(C)C)=O)C=C4OC)=N2)=CC=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GSK1838705A是高效，可逆的IGF-IR和胰岛素受体 (insulin receptor) 抑制剂，IC50值分别为2.0 和 1.6 nM。也可抑制ALK，IC50值为0.5 nM。 |
| IC50和靶点: | |
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Sabbatini, P., Korenchuk, S., Rowand, J.L., et al.GSK1838705A inhibits the insulin-like growth factor-1 receptor and anaplastic lymphoma kinase and shows antitumor activity in experimental models of human cancersMol. Cancer Ther.8(10),2811-2820(2009)
Zhou, X., Shen, F., Ma, P., et al.GSK1838705A, an IGF-1R inhibitor, inhibits glioma cell proliferation and suppresses tumor growth in vivoMol. Med. Rep.12(4),5641-5646(2015)
Zhou, F., Chen, X., Fan, S., et al.GSK1838705A, an insulin-like growth factor-1 receptor/insulin receptor inhibitor, induces apoptosis and reduces viability of docetaxel-resistant prostate cancer cells both in vitro and in vivoOnco Targets Ther.2015(8),753-760(2015)
