ASP3026
Cat. No.：YN440267
CAS No. ：1097917-15-1
规格
价格(RMB)
库存
| 产品名称: | ASP3026 |
| CAS No.: | 1097917-15-1 |
| Chemical Name: | N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-1,3,5-triazine-2,4-diamine |
| Synonyms: | ASP 3026 |
| 分子量: | 580.74 |
| 分子式: | C₂₉H₄₀N₈O₃S |
| SMILES: | COC(C=C(N1CCC(N2CCN(C)CC2)CC1)C=C3)=C3NC4=NC=NC(NC5=C(S(C(C)C)(=O)=O)C=CC=C5)=N4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ASP3026 是一种有效的，选择性的和具有口服活性的间变性淋巴瘤激酶 (ALK) 抑制剂。ASP3026 可诱导肿瘤细胞凋亡。ASP3026 可用于非小细胞肺癌 (NSCLC) 的研究。 |
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Mori, M., Ueno, Y., Konagai, S., et al.The selective anaplastic lymphoma receptor tyrosine kinase inhibitor ASP3026 induces tumor regression and prolongs survival in non-small cell lung cancer model miceMol. Cancer Ther.13(2),329-340(2015)
Fontana, D., Ceccon, M., Gambacorti-Passerini, C., et al.Activity of second-generation ALK inhibitors against crizotinib-resistant mutants in an NPM-ALK model compared to EML4-ALKCancer Med.4(7),953-965(2016)
