AZD-3463
Cat. No.：YN440334
CAS No. ：1356962-20-3
规格
价格(RMB)
库存
| 产品名称: | AZD-3463 |
| CAS No.: | 1356962-20-3 |
| Chemical Name: | N-[4-(4-amino-1-piperidinyl)-2-methoxyphenyl]-5-chloro-4-(1H-indol-3-yl)-2-pyrimidinamine |
| Synonyms: | ALK/IGF1R inhibitor |
| 分子量: | 448.95 |
| 分子式: | C₂₄H₂₅ClN₆O |
| SMILES: | ClC(C=NC(NC1=C(OC)C=C(N2CCC(N)CC2)C=C1)=N3)=C3C4=CNC5=C4C=CC=C5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AZD-3463 (ALK/IGF1R inhibitor) 是一种具有口服活性的ALK/IGF1R抑制剂，对 ALK 作用的Ki值为 0.75 nM。AZD-3463 可诱导神经母细胞瘤细胞凋亡 (apoptosis) 和自噬 (autophagy)。 |
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Wang, Y., Wang, L., Guan, S., et al.Novel ALK inhibitor AZD3463 inhibits neuroblastoma growth by overcoming crizotinib resistance and inducing apoptosisSci. Rep.6:19423,(2016)
Aquila, B., Kamhi, V., Peng, B., et al.Preparation of substituted pyrimidinamines as ALK kinase inhibitorsUS20120028924A1,1-54(2012)
